Workshop 6

Iron Toxicity

3 - 4 April 2003

Organizers

 A. Pietrangelo (Modena, Italy)
J.J.M. Marx (Utrecht, The Netherlands)		  

Sponsors

 European Commission QLRT-2001-00444
Novartis Pharma		  

Iron toxicity in iron overload diseases: chemical, biological and medical aspects

Session I

 

 Thursday

Chairs

 A. Pietrangelo (Modena, Italy) & A. McKie (London, UK) Abstract No.
9.40 Welcome and introduction
A. Pietrangelo (Modena, Italy)		  
9.50 - 10.30 Regulation of iron metabolism
J.J.M. Marx (Utrecht, The Netherlands)		  
10.30 -11.00 Genes involved in iron absorption and trafficking
A. McKie (London, UK)		  
11.00 - 11.15 coffee break  
     

Session II

    

Chairs

 P. Brissot (Rennes, France) & F. Visseren (Utrecht, The Netherlands) Abstract No.
11.15 - 11.45 Hemochromatosis
P. Brissot (Rennes, France)		  
12.15 - 12.45 Hepcidin in iron metabolism
O. Loreal (Rennes, France)		  
12.45 - 13.00 Discussion  
13.00

End of Session II  
13.00 - 14.00 Lunch / poster viewing  
     

Session III

    

Chairs

 J.J.M. Marx (Utrecht, The Netherlands) & Y. van der Schouw (Utrecht, The Netherlands) Abstract No.
15.00 - 15.15 Iron in cardiovascular diseases, epidemiological aspects
Y. van der Schouw (Utrecht, The Netherlands)		  
15.15 - 15.30 Iron in cardiovascular diseases, medical aspects
F.L.J. Visseren (Utrecht, The Netherlands)		  
15.30 - 15.45 Iron in cardiovascular diseases, biological aspects
N. Georgiou (Utrecht, The Netherlands)		  
15.45 - 16.00

Dietary heme iron and coronary heart disease
D.L. van der A, P.H.M. Peeters, D.E. Grobbee, and Y.T. van der Schouw (Utrecht, The Netherlands)

163
16.00 - 16.15 Iron modulates monocyte adherence to human endothelial cell monolayer
A.E.R. Kartikasari, N.A. Georgiou, H. van Kats-Renaud, F.L.J. Visseren, B.S. van Asbeck, and J.J.M Marx (Utrecht, The Netherlands) 		164
16.15 - 16.30 coffee break  
     

Session IV

    

Chairs

Z.I. Cabantchik (Jerusalem, Israel) & R.C. Hider (London, UK) Abstract No.
16.30 - 17.00 Non Transferrin Bound Iron: its nature and measurement
R.C. Hider, and D.Y. Liu (London, UK) 		165
17.00 - 17.30 Labile Plasma Iron (LPI), a novel indicator of chemically reactive iron in iron-overload
B. P. Esposito, W. Breuer, and Z.I. Cabantchik (Jerusalem, Israel) 		166
17.30 - 18.00 Discussion  
18.00 End of Session IV  
     

Session V

  Friday

Chairs

P. Aisen (New York, USA) & W. Koppenol (Zürich, Switzerland) Abstract No.
9.40 - 10.10 The uses and hazards of iron: a review of mechanisms and defenses
P. Aisen (New York, USA) 		167
10.10 - 10.35 Iron and redox cycling
D. Hofstetter, R. Kissner, and W.H. Koppenol (Zürich, Switzerland)		 168
10.35 - 11.00 Iron and radical reactions
M. Merkhofer, R. Kissner, A. Vanin, and W.H. Koppenol (Zürich, Switzerland) 		169
11.00 - 11.15 coffee break  
     

Session VI

    

Chairs

J.J.M. Marx (Utrecht, The Netherlands) & A. Pietrangelo (Modena, Italy) Abstract No.
11.15 - 11.45 Development of orally active iron chelators for the treatment of thalassaemia
R.C. Hider, and Z.D. Liu (London, UK) 		170
11.45 - 12.05 Update on the clinical development of the new oral iron chelator ICL670
D. Alberti (Origgio, Italy)		  
12.05 - 13.00 Round table discussion on toxicity of iron in biological fluids
P. Aisen (New York, USA)W.H. Koppenol (Zürich, Switzerland)R.C. Hider (London, UK)Z.I. Cabantchik (Jerusalem, Israel)		  
13.00 End of workshop